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Panel's Recommendations Regarding Co-receptor Tropism Assays
Panel's Recommendations
  • A co-receptor tropism assay should be performed whenever the use of a CCR5 co-receptor antagonist is being considered (AI).
  • Co-receptor tropism testing is also recommended for patients who exhibit virologic failure on a CCR5 antagonist (BIII).
  • A phenotypic tropism assay is preferred to determine HIV-1 co-receptor usage (AI).
  • A genotypic tropism assay should be considered as an alternative test to predict HIV-1 co-receptor usage (BII).
Rating of Recommendations: A = Strong; B = Moderate; C = Optional
Rating of Evidence: I = Data from randomized controlled trials; II = Data from well-designed nonrandomized trials or observational cohort studies with long-term clinical outcomes; III = Expert opinion

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